Tricyclic antidepressants are more likely to cause suicidal thoughts?


According to a study published online in BMC Medicine, tricyclic antidepressants are more likely to cause suicidal thoughts as compared to SSRI. According to the study, men taking nortriptyline were 2.4 times more likely to have suicidal thoughts than those taking Lexapro (SSRI compared). Nortiptyline was also associated with a 9.8 fold higher risk of suicidal ideation than the SSRI. According to Nader Perroud, MD, of Kings College London, and colleagues, the difference between the two drugs and prevalence of suicidal ideation is that nortiptyline acts primarily in the noradrenergic system; this system, when it is over active, is often associated with agitation and anxiety. The researchers put it this way, “suicidal idiation is more common in agitated and irritable types of depression… it is possible that nortiptyline may induce or worsen suicidal thoughts in some male subjects, possibly through an induction of this more agitated type of depression.” Click here to read an article from Pharma Times that discusses the findings more.

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